Colostrum/Immune Milk Studies

• Abraham, G.B., 1988. Process for preparing antibodies against E. coli K-99 antigen from bovine milk. US Patent No 4784850, 15 Nov 1988

• Antonio, J., Sanders, M.S., Van Gammern, D., 2001. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 17(3):243-247.

• Ashraf, H., Mahalanabis, D., Mitra, A.K., et al, 2001. Hyperimmune bovine colostrum in the treatment of shigellosis in children: a double-blind, randomized, controlled trial. Acta Paediatr 90:1373-1378.

• Bainter, K., 1986. Intestinal absorption of macromolecules and immune transmission from mother to young. CRC Press, Boca Raton, FL

• Bitzan, M.M., Gold, B.D., Philpott, D.J., et al, 1998. Inhibition of Heliobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. J Infect Dis.177:955-961.

• Boesman-Finkelstein, M., Finkelstein, R.A., et al, 1991. Bovine lactogenic immunity against pediatric enteropathogens. Immunology of Milk and the Neonate 361-367.

• Boesman-Finkelstein, M., Walton, N.E., Finkelstein, R.A.,1989. Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes Infection and Immunity 57, 1227-1234.

• Bolke, E., Jehle, P.M., Hausmann, F., et al, 2002. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. Shock 17:9-12.

• Bolke, E., Orth, K., Jehle, P.M., et al, 2002. Enteral application of an immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery--a randomized placebo-controlled pilot trial. Wien Klin Wochenschr 114:923-928.

• Brambell, F. W. R., 1969. In The Transmission of Passive Immunity From Mother to Young. Vol. 18. Am. Elsevier Publishing Co., New York.

• Bridger, J.C., Brown, J.F., 1981. Development of immunity to porcine rotavirus in piglets protected from disease by bovine colostrum. Infect Immun. 1981 Mar;31(3):906-910.

• Brussow, H., Hilpert, H., Walther, J., Sidoti, J., Meitens, C., and Bachman, P., 1987. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritus. J. Clin. Microbiol. 25: 982-986.

• Campbell, B., Petersen, W.E., 1963. Immune milk--a historical survey. Dairy Sci Abstr 25:345-358.

• Campbell, B., Petersen, W.E., 1959. Antibodies in milk for protection against human disease. Milchwissenschaft 14, 469-473.

• Casswall, T.H., Sarker, S.A., Albert, M.J., et al, 1998. Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Aliment Pharmacol Ther ; 12:563-568.

• Castrucci, G., Frigeri, F., Ferrari, F., Aldrovandi, V., Angelillo, V., Gatti, R., 1989. Immunization against bovine rotaviral infection. European Journal of Epidemiology 5, 279-284.

• Clark, D., Wyatt, K., 1996. Colostrum, Life’s First Food. Salt Lake City: CNR Publications

• Clarkson, M.J., Faull, W.B., Kerry, J.B., 1985. Vaccination of cows with clostridial antigens and passive transfer of clostridial antibodies from bovine colostrum to lambs. Vet Rec. Apr 27;116(17):467-9.

• Collins, A.M., et al, 1991. Bovine milk, including pasteurized milk, contains antibodies directed against allergens of clinical importance to man. Int Archiv of Allergy and Applied Immunology 96:362-367.

• Davidson, G.P., Whyte, P.B., Daniels, E., et al, 1989. Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet 1989;2:709-712.

• Donovan, S.M., Odle, J., 1994. Growth factors in milk as mediators of infant development. Annu Rev Nutr 14, 147-167.

• Ebina, T., Sato, A., Umezu, K., et al, 1984. Treatment of multiple sclerosis with anti-measles cow colostrum. Med Microbiol Immunol (Berl) 173:87-93.

• Ebina, T., Sato, A., Umezu, K., Ishida, N., Ohyama, S., Oizumi, A., Kitaoka, S., Suzuki, H., Kunno, T., 1985. Prevention of rotavirus infection by oral administration of cow colostrum containing antihuman rotavirus antibody. Med. Microbiol. Immunol., 174: 177-185.

• Facon, M., Skura, B.J., Nakai, S., 1993. Potential immunological supplementation of foods. Food and Agricultural Immunology 5, 85-91.

• Fernandez, .FM., Conner, M.E., Hodgins, et al, 1998. Passive immunity to bovine rotavirus in new-born calves fed colostrum supplements from cows immunised with recombinant SA 11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines. Vaccine 16, 507-516.

• Fernandez, L.B., Averbach, J., et al, 1973. Lyophilized bovine colostrum in the treatment of prolonged infantile diarrhea. American Journal of Clinical Nutrition 26, 383-384.

• Fidler, N., Koletzko, B., 2000. The fatty acid composition of human colostrum. Eur J Nutr 39(1): 31-37.

• Filler, S.J., Gregory, R.L., Michalek, S.M., et al, 1991. Effect of immune bovine milk on Streptococcus mutans in human dental plaque. Archives of Oral Biology 36, 41-47.

• Freedman, D.J., Tacket, C.O., Delehanty, A., et al, 1998. Milk immunoglobulin with specific activity against purified colonization factor antigens can protect against oral challenge with enterotoxigenic Escherichia coli. Journal of Infectious Diseases 177, 662-667.

• Gonzaga, A.J., Warren, R.J., Robbins, F.C., 1963. Attenuated poliovirus infection in infants fed colostrum from poliomyelitis immune cows. Pediatrics 30, 1039-1043.

• Gopal, P.K., Gill, H.S., 2000. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Brit J Nutr 84, Suppl 1, S69-S74.

• Graczyk, T.K., Cranfield, M.R., Bostwick, E.F., 1999. Hyperimmune bovine colostrum treatment of moribund Leopard geckos (Eublepharis macularius) infected with Cryptosporidium sp. Veterinary Research 30, 377-382.

• Graczyk, T.K., Cranfield, M.R., Helmer, P., Fayer, R., Bostwick, E.F., 1998. Therapeutic efficacy of hyperimmune bovine colostrum treatment against clinical and subclinical Cryptosporidium serpentis infections in captive snakes. Veterinary Parasitology 74, 123-132.

• Greenberg, P.D., Cello, J.P., 1996. Treatment of severe diarrhea caused by Crytosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Rretrovirol. 13:4,348-354.

• Groziak, S.M., Miller, G.D., 2000. Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system. Br J Nutr 84, Suppl 1, S119-25.

• Hagiwara, K., Kataoka, S., Yamanaka, H., Kirisawa, R., Iwai, H., 2000. Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol. Oct 31;76(3-4):183-90.

• He, F., Tuomola, E., Arvilommi, H., et al, 2001. Modulation of human humoral immune response through orally administered bovine colostrum. FEMS Immunol Med Microbiol 31(2):93-96.

• Hilpert, H., Brussow, H., Mietens, C., et al, 1987. Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. J Infect Dis 156:158-166.

• Hofman, Z., Smeets, R., Verlaan, G., et al, 2002. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab 12:461-469.

• Huppertz, H.I., Rutkowski, S., Busch, D.H., et al, 1999. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin-producing E. coli, and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr. 29:452-456.

• Ishida, A., Yoshikai, Y., Murosaki, S., Hidaka, Y., Nomoto, K., 1992. Administration of milk from cows immunised with intestinal bacteria protects mice from radiation-induced lethality. Biotherapy 5, 215-225.

• Janusz, M., et al, 1987. Immunoregulatory properties of synthetic peptides: fragments of a proline-rich polypeptide from bovine colostrum. Molecular Immunology 24(10): 1029-1031.

• Kelly, C., Pothoulakis, C., Vavva, F., Castagliolo, I., et al, 1996. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxin. Antimicrobial Agents and Chemotherapy 40, 373-379.

• Khan, Z., Macdonald, C., Wicks, A.C., et al, 2002. Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 16:1917-1922.

• Kobayashi, T., Ohmori, T., et al, 1991. Protective effect of orally administering immune milk on endogenous infection in X-irradiated mice. Agricultural and Biological Chemistry 55, 2265-2272.

• Korhonen, H., Marnila, P., Gill, H.S., 2000. Milk immunoglobulins and complement factors. Br J Nutri 84 Suppl 1:S75-80.

• Korhonen, H., et al, 2000. Bovine milk antibodies for health. Br J Nutr 84, Suppl 1, S135-46

• Korhonen, H., Syväoja, E.-L., Ahola-Luttila, H., et al, 1995. Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobacter pylori Journal of Applied Bacteriology 78:655-662.

• Kreider, R.B. et al. Effects of bovine colostrum supplementation in training adaptations I: Body composition. Med Sci Sports Exerc 33, Suppl. 5, May 2001, Abstract LB 316

• Lascelles, A.K., 1963. A review of the literature on some aspects of immune milk. Dairy Sci Abstr 25:359-364.

• Le Rousic, S., Klein, N., Houghton, S., Charleston, B., 2000. Use of colostrum from rotavirus-immunised cows as a single feed to prevent rotavirus-induced diarrhoea in calves. Vet Rec. Aug 5;147(6):160-161.

• Lissner, R., Thurmann, P.A., Merz, G., Karch, H., 1998. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows (Lactobin) to healthy volunteers. Int J Clin Pharmacol Ther. 36:239-245.

• Liotet, C.C., Kogbe, O., 1995. Treatment of Severe Eye Dryness and Problematic Eye Lesions with Enriched Bovine Colostrum Lactoserum. Lacrimal Gland, Tear Film, and Dry Eye Syndromes. New York, NY: Plenum Press; 595-599.

• Lodinova-Zadnikova, R., Korych, B., Bartakova, Z., 1987. Treatment of gastrointestinal infection in infants by oral administration of colostral antibodies. Die Nahrung 31, 465-467.

• Loimaranta, V., Laine, M., Soderling, E., et al, 1999. Effects of bovine immune and non-immune whey preparations on the composition and pH response of human dental plaque. Eur J Oral Sci 107:244-250.

• Loimaranta, V., Nuutila, J., Marnila, P., et al, 1999. Colostral proteins from cows immunised with Streptococcus mutans/Strep. sobrinus support the phagocytosis and killing of mutans streptococci by human leukocytes. Journal of Medical Microbiology 48, 1-10.

• Mach, J.P., Pahud, J.J., 1971. Secretory IgA, a major immunoglobulin in most bovine external secretions. J Immunol 1971;106:552-563.

• McClead, R.E. Jr., Butler, T., Rabbani, G.H., 1988. Orally administered bovine colostral anti-cholera toxin antibodies: results of two clinical trials. Am J Med 85:811-816.

• McClead, R.E. Jr., Gregory, S.A., 1984. Resistance of bovine colostral anti-cholera toxin antibody to in vitro and in vivo proteolysis. Infection and Immunity 44, 474-478.

• McGuire, T.C. et al, 1976. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J Am Vet Med Assoc 169, 713-718.• Mee, J.F., Mehra, R., 1995. Efficacy of colostrum substitutes and supplements in farm animals. Agro-Food-Industry Hi-Tech 6, 31-35.

• Mensik, J., 1978. Use of polyvalent cow colostrum in the prevention of enteric infections in calves and piglets. Ann Rech Vet. 9(2):255-258.

• Merendino, N., Prosperi, S., Franci, O., et al, 1996. Immunomodulatory activity of bovine colostrum on human peripheral blood mononuclear cells. J Nutr Immunol. 4:5-21.

• Mero, A., Miikkulainen, H., Riski, J., et al, 1997. Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone and saliva IgA during training. J Appl Physiol. 83: 1144-1151.

• Mietens, C., Keinhorst, H., Hilpert, H., et al, 1979. Treatment of infantile E. coli gastroenteritis with specific bovine anti-E. coli milk immunoglobulins. Eur. J. Ped. 132: 239-52.

• Mitra, A.K., Mahalanabis, D., Ashraf, H., et al, 1995. Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial. Acta Paediatr 84:996-1001.

• Morris, J. A., et al, 1980. Passive protection of lambs against enteropathogenic Escherichia coli: Role of antibodies in serum and colostrum. T. Med. Microbiol. 13: 265-271.

• Nord, J., Ma, P., DiJohn, D., et al, 1990. Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. AIDS 4:581-584.

• Nousiainen, J., Korhonen, H., et al, 1994. The effect of colostral immunoglobulin supplement on the passive immunity, growth and health of neonatal calves. Agricultural Science in Finland 3, 421-427.

• Ogra, P., et al, 1983. Colostrum derived immunity and maternal neonatal interaction.Annals NY Acad Sci 409:82-92.

• Okhuysen, P.C., Chappell, C.L., Crabb, J., et al, 1998. Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum. Clin Infect Dis 1998;26:1324-1329.

• Oona, M., Rigo, T., Maaroos, H., et al, 1997. Helicobacter pylori in children with abdominal complaints: has immune colostrum some influence on gastritis? Alpe Adria Microbiology J 6:49-57.

• Pahud, J. J., Hilbert, H., Schwartz, K., Amster, H., and Smiley, M., 1981. Bovine milk antibodies in the treatment of enteric infections and their ability to eliminate virulence factors from pathogenic E. coli. In: The Ruminant Immune System, edited by J. E. Butler:591-600. Plenum, New York.

• Palmer, E.L., et al, 1980. Antiviral activity of colostrum and serum immuno-globulins A and G.  J Med Virol 5:123-129

• Parodi, P.W., 2001. Cow's Milk Components With Anti-Cancer Potential. Australian Journal of Dairy Technology 56:65-73.

• Pedersen, A.M., Andersen, T.L., Reibelm J., et al, 2002. Oral findings in patients with primary Sjogren's syndrome and oral lichen planus--a preliminary study on the effects of bovine colostrum-containing oral hygiene products. Clin Oral Investig 6:11-20.

• Penhale, W. J., Logan, E. F., Selman, I. E., Fisher, E. W. and McEwan, A. D., 1973. Observations on the adsorption of colostral immunoglobulins by neonatal calf and their significance in colibacillosis. Ann. Rech. Vet. 4: 223-229.

• Perryman, L.E., Riggs, M.W., Mason, P.H. Fayer, R., 1990. Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum. Infection and Immunity 58, 257-259.

• Petschow, B.W., Talbott, R.D., 1994. Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastric acid and digestive enzymes. J Pediatr Gastroenterol Nutr. 19:228-235.

• Playford, R.J., Floyd, D.N., Macdonald, C.E., et al, 1999. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 44:653-658.

• Playford, R.J., Macdonald, C.E., Johnson, W.S., 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr Jul;72(1):5-14.

• Playford, R.J., et al, 2001. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci 100, 627-633.

• Plettenberg, A., Sthoehr, A., Stellbrink, H.J., et al, 1993. A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea. Clin Investig. 71:42-45.

• Popik, P., Bobula, B., Janusz, M., et al, 1999. Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats. Pharmacol Biochem Behav. 64:183-189.

• Quigley, J.D. et al, 2001. Formulation of colostrum supplements, colostrum replacers and acquisition of passive immunity in neonatal calves. J Dairy Sci 84, 2059-2065.

• Roos, N., Mahe, S., Benamouzig, R., et al, 1995. 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr. 125:5,1238-1244.

• Rump, J.A., Arndt, R., et al, 1992. Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clin Investig. 70:7,588-94.

• Sabin, A.B., 1950. Antipoliomylitic Substance in milk from Human Beings and Certain Cows. J Diseases of Children 80:866.

• Sabin, A. B. et.al, 1962. Antipoliomylitic activity of human and bovine Colostrum and milk. Pediatrics 29:105-115.

• Saif, L.J., Smith, K.L., Landemeier, B.J., et al, 1984. Immune response of pregnant cows to bovine rotavirus immunization. Am J of Vet Res 45:49-58.

• Sarker, S.A., Caswall, T.H., Mahalanabis, D., et al, 1998. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J. 17:1149-1154.

• Schlimme, E., et al, 2000. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Br J Nutr 84, Suppl 1, S59-68.

• Sharpe, S.J., Gamble, G.D., Sharpe, D.N., 1994. Cholesterol-lowering and blood pressure effects of immune milk. Am J Clin Nutr 59:929-934.

• Smith, T., Little, R. B., 1922. The significance of colostrum to the newborn calf. J. Exp. Med. 36:181-186.

• Solomons, N.W., 2002. Modulation of the immune system and the response against pathogens with bovine colostrum concentrates. Eur J Clin Nutr 56 Suppl 3:S24-8.

• Spik, G., et al, 1981. Bacteriostasis of a milk-sensitive strain of E. coli by immuno-globulins and iron-binding proteins associated with colostrum. Immunology 35:663-670.

• Stephan, W., Dichtelmuller, H., Lissner, R., 1990. Antibodies from colostrums in oral immunotherapy. J Clin Chem Clin Biochem 28:19-23.

• Tacket, C.O., Losonsky, G., Link, H., et al, 1988. Protection by milk immunoglobulin concentrate against oral challenge with enterogenic Escherichia coli. Eng. J. Med., 318: 1240-1241.

• Tacket, C.O., Binion, S.B., Bostwick, E., et al, 1992. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigellla flexneri challenge. Am J Trop Med Hyg. 47:276-283.

• Tischbein, H., 1976. IMPRO – A revolution in livestock health which uses antibodies rather than antibiotics. Countryside 60(8):14-20.

• Tollemar, J., Gross, N., Dolgiras, N., et al, 1999. Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow Transplantation 23:283-290.

• Tsunemitsu, H., Shimizu, M., Hirai, T., et al, 1989. Protection against bovine rotaviruses in new-born calves by continuous feeding of immune colostrum. Nippon Juigaku Zasshi 51: 300-308

• Tzipori,S., Roberton, D., Chapman, C., 1986. Remission of diarrhoea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. Br Med J 293:1276-1277.

• Tzipori, S., Robertson, D, Cooper, D.A., White, L., 1987. Chronic cryptosporidial diarrhoea and hyperimmune cow colostrum. Lancet 2:344-345.

• Ungar, B.L., Ward, D.J., Fayer, R., Quinn, C.A., 1990. Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology 98:486-489.

• van Hooijdonk, A.C., et al, 2000. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr 84, Suppl 1: S127-134.

• Vukavic, T., 1984. Timing of the gut closure. J Ped Gastroenterol Nutr 3:700-703.

• Wada, N., et al, 1980. Neutralizing activity against Clostridium difficile toxins in the supernatants of cultured colostral cells. Infect Immune 29:545-550.

• Warny, M., Fatimi, A., Bostwick, E.F., et al, 1999. Bovine immunoglobulin concentrate-Clostridium difficile retains C. difficile toxin neutralizing activity after passage through the human stomach and small intestine. Gut. 44:212-217.

• Weiner, C., Pan, Q., Hurtig, M., et al, 1999. Passive immunity against human pathogens using bovine antibodies. Clin Exper Immunology 116:193-205.