Lactoferrin Research

• Abe, H., Saito, H., Miyakawa, H., Tamura, Y., Shimamura, S., Nagao, E., and Tomita, M., 1991. Heat stability of bovine lactoferrin at acidic pH. Journal of Dairy Science 74, 65-71.

• Adamik, B., Zimecki, M., Wlaszczyk, A., et al., 1998. Lactoferrin effects on the in vitro immune response in critically ill patients. Arch Immunol Ther Exp (Warcz). 46:169-176.

• Arnold, D., Di Biase, A. M., Marchetti, M., Pietrantoni, A., Valenti, P., Seganti, L. and F. Superti, 2002. Antiadenovirus activity of milk proteins: lactoferrin prevents viral infection. Antiviral Res. 53:153-158.

• Al-Nabulsi, A.A., Holley, R.A., 2006. Enhancing the antimicrobial effects of bovine lactoferrin against Escherichia coli O157:H7 by cation chelation, NaCl and temperature. Journal of Applied Microbiology, Volume 100, Number 2, pp. 244-255(12).

• Azuma, N., Mori, H., Kaminogawa, S., Yamauchi, K., 1989. Stimulating effect of lactoferrin on DNA synthesis in BALB/c3T3 cell. Agric. Biol. Chem. 53:31-35.

• Baveye, S., Elass, E., Mazurier, J., et al. 1999. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med. 37:281-286.

• Bellamy, W., Takase, M., Yamauchi, K., Wakabayashi, H., Kawase, K., Tomita, M., 1992. Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta 1121, 130-136.

• Britigan, B.E., Serody, J.S., Cohen, M.S., 1994. The role of lactoferrin as an anti-inflammatory molecule. Adv Exp Med Biol. 357:143-156.

• Cornish, J., et al, 2004. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145(9):4366-74.

• Di Biase, A. M., et al, 2003. Heparin-interacting sites of bovine lactoferrin are involved in anti-adenovirus activity. J. Med. Virol. 69:495-502.

• Dionysius, D.A., Milne J.M., 1997. Antibacterial peptides of bovine lactoferrin: purification and characterization. Journal of Dairy Science 80, 667-674.

• Fujihara, T., Hayashi, K., 1995. Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection in mouse cornea. Arch. Virol. 140:1469-1472.

• Hambraeus, L., Lönnerdal, B., 1994. The physiological role of lactoferrin. IDF Bulletin: Indigenous Antimicrobial Agents of Milk: Recent Developments: 97-107.

• Hara, K., et al, 2002. Lactoferrin inhibits hepatitis B virus infection in cultured human hepatocytes. Hepatol. Res. 24:228-235.

• Harmsen, M. C., et al, 1995. Antiviral effects of plasma and milk proteins: lactoferrin shows a potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J. Infect. Dis. 172:380-388.

• Hasegawa, K., Motsuchi,W., Tanaka, S., Dosako, S., 1994. Inhibition with lactoferrin of in vitro infection with human herpesvirus. Jpn. J. Med. Sci. Biol. 47:73-85.

• Hoek, K.S., Milne, J.M., Grieve, P.A., Dionysius, D.A., Smith, R., 1997. Antibacterial activity of bovine lactoferrin derived peptides. Antimicrobial Agents and Chemotherapy 41, 54-59.

• Hurley, W.L., Grieve, R.C.J., Magura, C.E., Hegarty, H.M., Zou, S. 1993. Electrophoretic comparisons of lactoferrin from bovine mammary secretions, milk neutrophils, and human milk. Journal of Dairy Science 76, 377-387.

• Iigo, M., et, al, 2004. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine, 25(1): 36-44.

• Ikeda M, Nozak A, Sugiyama K, et al. Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res. 2000; 66:51-63.

• Iwasa, M., et al, 2002. Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b. Am. J. Gastroenterol. 97:766-767.

• Ikeda, M., et al, 1998. Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochem. Biophys. Res. Commun. 215:744-749.

• Johansson, B., 1960. Isolation of an iron-containing red protein from human milk. Acta Chem. Scand. 14:510-512.

• Jones, E.M., Smart, A., Bloomberg, G., Burgess, L.,Millar, M. R.,1994. Lactoferricin, a new antimicrobial peptide. J. Appl. Bacteriol. 77:208-214.

• Kawasaki, Y., et al, 1993. Inhibition by casein glycomacropeptide and lactoferrin of influenza virus hemagglutination. Biosci. Biotech. Biochem. 57:1214-1215.

• Kawasaki, Y., Isoda, H., Tanimoto, M., Dosako, S., Idota, T., Ahiko, K., 1992. Inhibition by lactoferrin and casein glycomacropeptide of binding of cholera toxin to its receptor. Biosci. Biotech. Biochem. 56:195-198.

• Kutila, T., et al, 2004. The efficacy of bovine lactoferrin in the treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology & Therapeutics. 27(4):197-202.

• Levay, P.F., Viljoen, M., 1995. Lactoferrin: a general review. Haemtologica. 80:252-267.

• Lonnerdal, B., Iyer, S., 1995. Lactoferrin: molecular structure and biological function. Annu Rev Nutr. 15:93-110.

• Luf, W., Rosner, E., 1997. Zur Thermostabilität von Lactoferrin in Kuhmilch. Wiener Tieraertzliche Monatsschrift. 84, 70-73.

• Magnusson, J.S., Henry, J.H., Yip, T-T., Hutchens, T.W., 1990. Structural homology of human, bovine, and porcine milk lactoferrins: evidence for shared antigenic determinants. Pediatric Research 28, 176-181.

• Marchetti, M., et al, 1996. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 29:221-231.

• McCann, K.B.; Lee, A.; Wan, J.; Roginski, H.; Coventry, M.J., 2003. The effect of bovine lactoferrin and lactoferricin B on the ability of feline calcivirus (a notovirus surrogate) and poliovirus to infect cell cultures. Journal of Applied Microbiology. 95(5):1026-1033.

• Mitoma, M., Oho, T., Shimazaki, Y., Koga, T., 2001. Inhibitory effect of bovine milk lactoferrin on the interaction between a streptococcal surface protein antigen and human salivary agglutinin. J. Biol. Chem. 276:18060-18065.

• Moore, S.A., Anderson, B.F., Groom, C.R., Haridas, M., Baker, E.N., 1997. Three-dimensional structure of diferric bovine lactoferrin at 2·8 Å resolution. Journal of Molecular Biology 274: 222-236.

• Naot, D., Grey, A.,Reid, I.R., Cronish, J., 2005. Lactoferrin--a novel bone growth factor. Clin. Med. Res. 3(2):93-101.

• Oho, T., Mitoma, M. & Koga, T., 2002. Functional domain of bovine milk lactoferrin which inhibits the adherence of Streptococcus mutans cells to a salivary film. Infect. Immun. 70:5279-5282.

• Oria, R., Ismail, M., Sanchez, L., Calvo, M., Brock, J. H., 1993. Effect of heat treatment and other milk proteins on the interaction of lactoferrin with monocytes. J. Dairy Res. 60:363-369.

• Paulsson, M.A., Svensson, U., Kishore, A.R., Naidu, A.S., 1993. Thermal behaviour of bovine lactoferrin in water and its relation to bacterial interaction and antibacterial activity. J Dairy Sci 76: 3711-3720.

• Pierce A, et al, 1991. Molecular cloning and sequence analysis of bovine lactoferrin. Eur J Biochem 196, 177-184.

• Pietrantoni, A., et al, 2003. Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides. Antimicrobial Agents and Chemotherapy 47(8): 2688-2691.

• Reiter, B., 1985. The biological significance of the non-immunoglobulin protective proteins in milk. Dev Dairy Chemi 3: 281-336.

• Renner, E., Schaafsma, G., Scott, K.J., 1989. Micronutrients in milk. Micronutrients in Milk and Milk-based Food Products :1-70.

• Sanchez, L., Calvo, M., Brock, J.H., 1992. Biological role of lactoferrin. Archives of Disease in Childhood 67, 657-661.

• Sanchez, L., et al, 1992. Kinetic parameters for denaturation of bovine milk lactoferrin. J Food Sci 57: 873-879.

• Schanbacher, F.L., Talhouk, R.S., Murray, F.A., 1997. Biology and origin of bioactive peptides in milk. Livestock Production Science 50, 105-123.

• Schulz-Lell, G., Dorner, K., Oldigs, H.-D., Sievers, E., Schaub, J., 1991. Iron availability from an infant formula supplemented with bovine lactoferrin. Act. Paediatr. Scand. 80:155-158.

• Sekine K, et al, 1997. Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin adminsitration in F344 rats. Japanese Journal of Cancer Research 88: 523-526.

• Shimazaki, K., 2000. Lactoferrin: a marvelous protein in milk? Anim. Sci. J. 71:329-347.

• Shimazaki K­I, et al, 2000. Lactoferrin: Structure, Function and Applications. Exerpta Medica International Congress Series 1195.

• Shimazaki K-I, et al, 1993 Analysis of human and bovine milk lactoferrins by rotofor and chromatofocussing. Int J Biochem 25:1653-1658.

• Shimizu K, et al, 1996. Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell dependent augmentation of natural killer cell activity. Archives of Virology 141:1875-1889.

• Spik, G., Legrand, D., Mazurier, J., Pierce, A., Perraudin, J-P., 1998. Advances in lactoferrin research. Advances in Experimental Medicine and Biology V.443.

• Steijns, J. M., 2001. Milk ingredients as nutraceuticals. Int. J. Dairy Technol. 54:81-88.

• Steijns, J.M., van Hooijdonk, A.C., 2000. Occurrence, structure, biochemical properties and technological characteristics of lactoferrin. Br J Nutr 84 Suppl 1:S11-7.

• Superti, F., Ammendolia, M.G., Valenti, P., Seganti, L., 1997. Anti-rotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29. Med. Microbiol. Immunol. 186:83-91.

• Swart PJ, Kuipers EM, Smit C et al, 1998. Lactoferrin. Antiviral activity of lactoferrin. Adv Exp Med Biol 4434:205-13.

• Tanaka T., Nakatani S., Xuan X., Kumura H., Igarashi I., Shimazaki K., 2003. Antiviral activity of lactoferrin against canine herpesvirus. Antiviral Res. 60(3):193-199.

• Takeuchi T., Shimizu H., Ando K., Harada E., 2004. Bovine lactoferrin reduces plasma triacylglycerol and NEFA accompanied by decreased hepatic cholesterol and triacylglycerol contents in rodents. Br J Nutr 91(4):533-538.

• Tomita, M., Takse, M., Wakabayashi, H., Bellamy, W., 1994. Antimicrobial peptides of lactoferrin. Adv Exp Med and Bio 357:209-218.

• Tomita, M., Bellamy, W. R., Takase, M., Yamauchi, K., Wakabayashi, H., Kawase, K.,1991. Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin. J Dairy Sci. 74:4137-4142.

• Trumpler, U., Straub, P.W., Rosenmund, A., 1989. Antibacterial prophylaxis with lactoferrin in neutropenic patients. Eur J Clin Microbiol Infect Dis. 8:310-313.

• Valenti, P., et al, 1998. Antiviral activity of lactoferrin, p. 199-203. In Spik, G. et al (eds.), Advances in lactoferrin research. Plenum Press, New York, N.Y.

• Vorland, L.H., 1999. Lactoferrin: a multifunctional glycoprotein. APMIS. 107:971-981.

• Vorland, L.H., Ulvatne, H., Andersen, J., et al, 1999. Antibacterial effects of lactoferricin. B. Scand J Infect Dis. 31:179-184.

• Wong, D.W.S., Camirand, W. M., Pavlath, A. E., 1996. Structures and functionalities of milk proteins. Crit. Rev. Food Sci. Nutr. 36:807-844.

• Yang N., Rekdal Ø., Stensen W., Svendsen J.S., 2002. Enhanced antitumor activity and selectivity of lactoferrin-derived peptides. J Peptide Res 60(4):187-197.

• Zimecki, M., Wlaszczyk, A., Cheneau, P., et al, 1998. Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals. Arch Immunol Ther Exp (Warcz). 46:231-240.

• Zimecki, M., Mazurier, J., Machnicki, M., Wieczorek, Z., Montreuil, J., Spik, G., 1991. Immunostimulatory activity of lactoferrin and maturation of CD4-, CD8-murine thymocytes. Immunology Letters 30:119-123.